Glucentra
Antidiabetic
About
Glucentra® is a brand of Metformin Hydrochloride and Glibenclamide Capsules with a combination of 250mg Metformin Hydrochloride and 1.25mg Glibenclamide. It is a hypogycemic agent used in the treatment of type 2 diabetes mellitus in adults as replacement for previous combination therapy with metformin and glibenclamide in patients whose glycaemia is stable and well-controlled.
Administration
Glucentra® dosage regimen depends on the individual posology:
• Once a day, in the morning at breakfast, for a dosage of 1 tablet/day,• Twice a day, morning and evening, for a dosage of 2 or 4 tablets/day,
• Three times a day, morning, noon and evening, for a dosage of 3, 5 or 6 tablets/day.
The tablets should be taken with meals. The dosage regimen should be adjusted according to the individual eating habits. However, any intake must be followed by a meal with a sufficiently high carbohydrate content to prevent the onset of hypoglycaemic episodes.
Side Effects
Glucentra® may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: The most common side effects are nausea, vomiting, diarrhoea, abdominal pain and loss of appetite which resolve spontaneously in most cases. To prevent them, it is recommended to take Glucentra® in 2 or 3 daily doses and to slowly increase the doses.
Prescription Information
Glucentra® is indicated in the treatment of type 2 diabetes in adults, as replacement for previous combination therapy with metformin and glibenclamide in patients whose glycaemia is stable and well-controlled. Treatment should be initiated with a dose of the combination product equivalent to previous individual doses of metformin and glibenclamide; the dose being gradually increased depending on results on glycaemic parameters. The dosage should be adjusted every 2 weeks or longer, by increments of 1 tablet, depending on glycaemia results. A gradual increase in the dosage may aid gastrointestinal tolerance and prevent the onset of hypoglycaemia. For detailed information about Glucentra, consult your doctor.
